The 56-year-old talk show host, who is married to 'Arrested Development' actress Portia de Rossi, secured the top spot on Out magazine's 2014 Power List, an annual ranking of the most influential LGBT (Lesbian, Gay, Bisexual and Transgender) voices in American culture.
Announcing the news on its website, the publication stated: "Everybody loves Ellen, and that's one of the reasons she's regained the top spot. In March, 'The Ellen DeGeneres Show' shattered its own 10-year ratings record in the episode that immediately followed her Academy Awards hosting gig, which also gave the awards its best ratings since 2004. And her star-studded Oscars selfie almost shut down Twitter when the pic became the most retweeted ever."
Other notable names on this year's list include fashion designers Tom Ford and Marc Jacobs, 'Good Morning America' host Robin Roberts, 'How I Met Your Mother' star Neil Patrick Harris, CNN anchor Anderson Cooper and 'Glee' actress Jane Lynch.
'Juno' actress Ellen Page made her debut at number 29 after coming out on Valentine's Day (14.02.14).
The 'Inception' star, 27, previously admitted she was scared to open up about her sexuality for a long time.
She said: "I suffered for years because I was scared to be out.
"My spirit suffered, my mental health suffered and my relationships suffered."