The 49-year-old actress - who shot to fame playing Monica Geller in the hit sit-com - is adamant a reunion programme would never happen because she finds it difficult to even get former co-stars Jennifer Aniston, Lisa Kudrow, Matthew Perry, Matt LeBlanc and David Schwimmer together for social gatherings.
She said: "Let me tell you something: there's six friends and I've been trying to put together a cast dinner for 10 years. It doesn't happen! I can get the girls to come, maybe Matthew Perry. Matt LeBlanc canceled last time right at the last minute, Schwimmer lives here [in New York City], so it's just not gonna happen."
The 'Cougar Town' actress gets tired of being asked about a possible reunion because her answers always get her into "trouble".
Asked by talk show host David Letterman if she is tired of the questions, she said: "Only because once you say, 'Well, I'd like it,' then they have to contact every other cast member and be like, 'Courteney's into it!' And then I get in trouble. It's not going to happen."
And the brunette star doesn't think there is much scope for a reunion story if the cast agreed to return to the programme, which ended in 2004 after 10 years.
She said: "We did the whole show on a soundstage in Monica's apartment. So what are you gonna do?"