An American Werewolf in London (1981)

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David Kessler and his buddy Jack Goodman trek across the north of England with their backpacks, stopping off for a drink at a pub called The Slaughtered Lamb. Told by the locals to stick to the road, the American visitors pay no heed to the advice and head onto the moors where a large wolf kills Jack and badly injures David. He recuperates in a London hospital under the care of nurse Alex Price, unaware that he is now a werewolf at the mercy of the moon.