Requiem for a Dream (2000)

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Sara is a lonely widow who has rediscovered her lust for life when faced with the possibility of appearing on television. Her son Harry, his girlfriend Marion and best bud Harry, have dreams of their own to set up a business peddling soft drugs to the gluttonous masses. All four characters soon witness their aspirations falling apart about them, yet they refuse to be down-hearted, even when fate deals them even greater and far more serious blows.