The Sports Illustrated model hits the big screen alongside Cameron Diaz and Leslie Mann in the comedy which follows the three women on a mission to get revenge on their three-timing lover, Mark - played by Game of Thrones' Nikolaj Coster-Waldau.
Upton, 21, believes the film will appeal to men because most can leave feeling smug about being a faithful partner after watching cheating Mark on screen.
Talking on US chat show 'Jimmy Kimmel Live' on Wednesday (09.04.14), she said: "I think that when they go to the movie they'll feel better about themselves. They'll be like 'I missed Valentines Day but I'm not that bad'."
Jimmy replied: "You look good by comparison."
She said: "Exactly, exactly. Suddenly, their wives and girlfriends will be like 'I like you a lot better.'"
Upton - who is best known for appearances in the Sports Illustrated Swimsuit Issue - has her first big film part in the Nick Cassavetes-directed picture which was released in the US and UK this month.